Pharmaceutical excipient for oral preparations POVACOAT® was listed as a Japanese Pharmaceutical Excipient (JPE) in December 2012. In terms of chemical structure, it is a synthetic polymer produced by the copolymerization of partially-saponified polyvinyl alcohol with acrylic acid and methyl methacrylate. POVACOAT offers a dense and strong film structure and is used in film coatings to add oxygen barrier effects and moisture-resistance. It also serves as a high-performance binder that offers high binding strength and reduces problems in tablet manufacturing.
(Listed as a Japanese Pharmaceutical Excipient (JPE) in December 2012.)
|Generic name||PVA copolymer|
|Drug name||Copolymer of polyvinyl alcohol, acrylic acid and methyl methacrylate|
|Drug Master File||Registered|
|Precedent use||72 mg per day (Administration: oral)|
|Type||F||MP||FL (Under development)|
|Properties (Appearance)||White to yellowish-white lump or powder||White to yellowish-white powder||Slightly yellow, transparent liquid|
|Specifications||JPE||JPE||To be discussed|
|Viscosity (mPa•s) (For reference)||5.5||5.5||5.5|
|Average molecular weight||Approx. 40,000||Approx. 40,000||Approx. 40,000|
|Average particle diameter||Approx. 1.5 mm||Approx. 125μm||
|Applications||Film coating, wet granulation binder||Wet granulation binders, solid dispersion substrates||Wet granulation binders for film coatings|
Contact us for our microparticle version of POVACOAT (developed upon request).