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SANGELOSE® is a new type of cellulose ether in which hydroxypropyl methylcellulose (HPMC), a derivative of cellulose (pulp), is modified with a stearyl group. Having a hydrophobic stearyl group in the molecule allows it to exhibit a variety of properties such as excellent surface activating properties and thickening properties. SANGELOSE is widely used in pharmaceutical and cosmetic gels, creams and alcohol preparations to provide smoothing effects and increase viscosity. The “smoothing” effect of the stearyl group also promises the use of SANGELOSE in haircare products to improve texture as a replacement for silicone. (Listed as a Japanese Pharmaceutical Excipient (JPE) in December 2012.)
| Pharmaceutical excipient | Hydrophobic hydroxypropyl methylcellulose |
|---|---|
| INCI name | Hydroxypropyl Methylcellulose Stearoxy Ether |
| Drug Master File | Registered |
| Precedent use | (Drugs) 0.9% (Quasi-drugs) 1.0% |
| Grade | Molecular weight | Stearyl group (wt%) | Solubility |
|---|---|---|---|
| 60L | Middle | 0.3-0.6 | Soluble in water |
| 90L | High | 0.3-0.6 | Soluble in water |
| 60M | Middle | 1.0-2.0 |
Insoluble in water. Soluble in mixture of water and ethanol. |
| 90M※1 | High | 1.0-2.0 | Insoluble in water. Soluble in mixture of water and ethanol. |
*1) 90M is manufactured on a custom-order basis.
